As a kind of endogenous noncoding R

As a kind of endogenous noncoding RNA with extensive regulatory functions, microRNAs (miRNAs) canregulate the expression of target genes by binding to the3’-untranslated region (3’-UTR) of target genes and thenparticipate in a series of life processes such as apoptosis,proliferation, and differentiation.10) Broad evidence has demonstrated that miRNAs widely exist in myocardial tissues and paly a regulatory role in the pathophysiologicalprocesses of cardiovascular diseases, including MI.11,12)Some miRNAs have been shown to promote or inhibitcardiomyocyte apoptosis through regulating the expressions of related target genes, thus, participating in the occurrence and development of MI.13-16) MiR-134-5p is akind of miRNAs, which was indispensable for cell differentiation, proliferation, and migration.17) It was reportedthat plasma miR-134-5p level was significantly increasedin early stage of AMI, which had potential diagnosticvalue for the early phase of AMI.18) However, the underlying mechanisms of miR-134-5p in MI have not been explored