Informal caregivers play a vital role in providingphysical and emotional support for cancer patients. The majority of informal cancer caregivers are notprepared for their caregiving role. Technology-mediated interventions have the potential todeliver efficient, scalable support and improve keyinformal caregiver outcomes, such as burden, distress,and QoL. Informal caregivers of older adults with cancer may beat greater risk for poor QoL and physical health. Informal caregiver research priorities should includeinnovative/scalable interventions that are personalizedto the caregiver/patient’s unique illness context andQoL needs.