A study from 1992 was the first to report the use of the calcium channel blocker verapamil in the treatment of keloids and hypertrophic scars.29 Dong found that in a few hours after the exposure to verapamil, monolayer cultures of bipolar-shaped fibroblasts-like cells gradually become spherical. They were considered to be calcium channel blockers that after actin filaments, depolymerization led to changes in cell morphology, and eventually induced the formation of a more circular shape of fibroblasts and easy to change shapes. Then, they cultivate a three-dimensional cell after surgical resection of six patients hypertrophic scar fibroblasts.