Background: Despite the increasing

Background: Despite the increasing use of pre- and post-hydration protocols and low osmolar instead of highosmolar iodine containing contrast media, the incidence of contrast induced nephropathy (CIN) is still significant.There is evidence that contrast media cause ischemia reperfusion injury of the renal medulla. Remote ischemicpreconditioning (RIPC) is a non-invasive, safe, and low cost method to reduce ischemia reperfusion injury. Theaim of this study is to investigate whether RIPC, as an adjunct to standard preventive measures, reduces contrastinduced acute kidney injury in patients at risk of CIN.Methods: The RIPCIN study is a multicenter, single blinded, randomized controlled trial in which 76 patients atrisk of CIN received standard hydration combined with RIPC or hydration with sham preconditioning. RIPC wasapplied by four cycles of 5 min ischemia and 5 min reperfusion of the forearm. The primary outcome measurewas the change in serum creatinine from baseline to 48 to 72 hours after contrast administration.Results: With regard to the primary endpoint, no significant effect of RIPC was found. CIN occurred in four patients(2 sham and 2 RIPC). A pre-defined subgroup analysis of patients with a Mehran risk score 11, showed asignificantly reduced change in serum creatinine from baseline to 48 to 72 hours in patients allocated to the RIPCgroup (D creatinine 3.3 9.8 mmol/L) compared with the sham group (D creatinine þ17.8 20.1 mmol/L).Conclusion: RIPC, as an adjunct to standard preventive measures, does not improve serum creatinine levels aftercontrast administration in patients at risk of CIN according to the Dutch guideline. However, the present dataindicate that RIPC might have beneficial effects in patients at a high or very high risk of CIN (Mehran score 11).The RIPCIN study is registered

Background: Despite the increasing use of pre- and post-hydration protocols and low osmolar instead of highosmolar iodine containing contrast media, the incidence of contrast induced nephropathy (CIN) is still significant.There is evidence that contrast media cause ischemia reperfusion injury of the renal medulla. Remote ischemicpreconditioning (RIPC) is a non-invasive, safe, and low cost method to reduce ischemia reperfusion injury. Theaim of this study is to investigate whether RIPC, as an adjunct to standard preventive measures, reduces contrastinduced acute kidney injury in patients at risk of CIN.Methods: The RIPCIN study is a multicenter, single blinded, randomized controlled trial in which 76 patients atrisk of CIN received standard hydration combined with RIPC or hydration with sham preconditioning. RIPC wasapplied by four cycles of 5 min ischemia and 5 min reperfusion of the forearm. The primary outcome measurewas the change in serum creatinine from baseline to 48 to 72 hours after contrast administration.Results: With regard to the primary endpoint, no significant effect of RIPC was found. CIN occurred in four patients(2 sham and 2 RIPC). A pre-defined subgroup analysis of patients with a Mehran risk score 11, showed asignificantly reduced change in serum creatinine from baseline to 48 to 72 hours in patients allocated to the RIPCgroup (D creatinine 3.3  9.8 mmol/L) compared with the sham group (D creatinine þ17.8  20.1 mmol/L).Conclusion: RIPC, as an adjunct to standard preventive measures, does not improve serum creatinine levels aftercontrast administration in patients at risk of CIN according to the Dutch guideline. However, the present dataindicate that RIPC might have beneficial effects in patients at a high or very high risk of CIN (Mehran score  11).The RIPCIN study is registered

0/5000

源语言: -

目标语言: -

结果 (简体中文) 1: [复制]

复制成功！

背景：尽管越来越多地使用水合前后的方案，并使用低渗透压而不是高 渗透压的碘作为造影剂，但造影剂诱发的肾病（CIN）的发生率仍然很高。 有证据表明造影剂引起肾髓质缺血再灌注损伤。远程缺血 预处理（RIPC）是一种减少缺血性再灌注损伤的非侵入性，安全且低成本的方法。 这项研究的目的是研究作为标准预防措施的辅助手段，RIPC是否可以减少造影剂 引起的CIN风险急性肾损伤。 方法：RIPCIN研究是一项多中心，单盲，随机对照试验，其中76例患者 CIN接受标准水合RIPC或深水预处理水合的风险。 通过缺血5分钟和前臂再灌注5分钟的四个周期应用RIPC 。主要结果指标 是对比剂给药后血清肌酐从基线到48至72小时的变化。 结果：关于主要终点，未发现RIPC有明显效果。4例患者发生了CIN （2例假手术和2例RIPC）。对Mehran风险评分≤11的患者进行的预先定义的亚组分析显示 ，与RIPC 组相比，血清肌酐从基线水平下降到48小时至72小时明显减少（D肌酐≤3.3≤9.8 mmol / L）。假手术组（D肌酐þ17.8？20.1 mmol / L）。 结论： 根据荷兰指南，对于有CIN风险的患者，在进行对比剂管理后，作为标准预防措施的辅助手段，RIPC不能改善血清肌酐水平。但是，目前的数据 表明，RIPC可能对具有高或非常高CIN风险的患者（Mehran得分≥11）具有有益的作用。 RIPCIN研究已注册

正在翻译中..

结果 (简体中文) 2:[复制]

复制成功！

Background: Despite the increasing use of pre- and post-hydration protocols and low osmolar instead of high osmolar iodine containing contrast media, the incidence of contrast induced nephropathy (CIN) is still significant. There is evidence that contrast media cause ischemia reperfusion injury of the renal medulla. Remote ischemic preconditioning (RIPC) is a non-invasive, safe, and low cost method to reduce ischemia reperfusion injury. The aim of this study is to investigate whether RIPC, as an adjunct to standard preventive measures, reduces contrast induced acute kidney injury in patients at risk of CIN. Methods: The RIPCIN study is a multicenter, single blinded, randomized controlled trial in which 76 patients at risk of CIN received standard hydration combined with RIPC or hydration with sham preconditioning. RIPC was applied by four cycles of 5 min ischemia and 5 min reperfusion of the forearm. The primary outcome measure was the change in serum creatinine from baseline to 48 to 72 hours after contrast administration. Results: With regard to the primary endpoint, no significant effect of RIPC was found. CIN occurred in four patients (2 sham and 2 RIPC). A pre-defined subgroup analysis of patients with a Mehran risk score 11, showed a significantly reduced change in serum creatinine from baseline to 48 to 72 hours in patients allocated to the RIPC group (D creatinine 3.3 9.8 mmol/L) compared with the sham group (D creatinine þ17.8 20.1 mmol/L). Conclusion: RIPC, as an adjunct to standard preventive measures, does not improve serum creatinine levels after contrast administration in patients at risk of CIN according to the Dutch guideline. However, the present data indicate that RIPC might have beneficial effects in patients at a high or very high risk of CIN (Mehran score 11). The RIPCIN study is registered

正在翻译中..

结果 (简体中文) 3:[复制]

复制成功！

背景：尽管越来越多地使用水化前和后水化方案，低渗透性而不是高渗透性 渗透压碘造影剂对造影剂诱发肾病（CIN）的发生率仍有显著影响。 有证据表明造影剂可引起肾髓质缺血再灌注损伤。远端缺血 预处理是一种无创、安全、低成本的减轻缺血再灌注损伤的方法。这个 本研究的目的是探讨RIPC作为标准预防措施的一种辅助手段，是否会降低对比度 CIN危险患者的诱发急性肾损伤。 方法：RIPCIN研究是一项多中心、单盲、随机对照试验，共有76名患者 接受标准水化联合RIPC或水化加假预处理的CIN风险。RIPC是 前臂缺血5min，再灌注5min为4个周期。主要结果指标 对比剂给药后48至72小时血清肌酐的变化。 结果：对于主要终点，RIPC无明显影响。4例发生CIN （2个假手术和2个RIPC）。对Mehran风险评分为 11的患者进行的预先定义的亚组分析显示 RIPC组患者从基线检查到48到72小时的血清肌酐变化显著减少 组（D肌酐3.3～9.8mmol/L）与假手术组（D肌酐17.8～20.1mmol/L）比较。 结论：RIPC作为标准预防措施的一种辅助手段，并不能改善术后血清肌酐水平 根据荷兰指南，对有CIN风险的患者进行对比给药。然而，目前的数据 提示RIPC对CIN高风险或非常高风险的患者可能有有益的效果（Mehran评分 11）。 瑞普信研究已注册

正在翻译中..

其它语言

本翻译工具支持: 世界语, 丹麦语, 乌克兰语, 乌兹别克语, 乌尔都语, 亚美尼亚语, 伊博语, 俄语, 保加利亚语, 信德语, 修纳语, 僧伽罗语, 克林贡语, 克罗地亚语, 冰岛语, 加利西亚语, 加泰罗尼亚语, 匈牙利语, 南非祖鲁语, 南非科萨语, 卡纳达语, 卢旺达语, 卢森堡语, 印地语, 印尼巽他语, 印尼爪哇语, 印尼语, 古吉拉特语, 吉尔吉斯语, 哈萨克语, 土库曼语, 土耳其语, 塔吉克语, 塞尔维亚语, 塞索托语, 夏威夷语, 奥利亚语, 威尔士语, 孟加拉语, 宿务语, 尼泊尔语, 巴斯克语, 布尔语(南非荷兰语), 希伯来语, 希腊语, 库尔德语, 弗里西语, 德语, 意大利语, 意第绪语, 拉丁语, 拉脱维亚语, 挪威语, 捷克语, 斯洛伐克语, 斯洛文尼亚语, 斯瓦希里语, 旁遮普语, 日语, 普什图语, 格鲁吉亚语, 毛利语, 法语, 波兰语, 波斯尼亚语, 波斯语, 泰卢固语, 泰米尔语, 泰语, 海地克里奥尔语, 爱尔兰语, 爱沙尼亚语, 瑞典语, 白俄罗斯语, 科西嘉语, 立陶宛语, 简体中文, 索马里语, 繁体中文, 约鲁巴语, 维吾尔语, 缅甸语, 罗马尼亚语, 老挝语, 自动识别, 芬兰语, 苏格兰盖尔语, 苗语, 英语, 荷兰语, 菲律宾语, 萨摩亚语, 葡萄牙语, 蒙古语, 西班牙语, 豪萨语, 越南语, 阿塞拜疆语, 阿姆哈拉语, 阿尔巴尼亚语, 阿拉伯语, 鞑靼语, 韩语, 马其顿语, 马尔加什语, 马拉地语, 马拉雅拉姆语, 马来语, 马耳他语, 高棉语, 齐切瓦语, 等语言的翻译.