As the main content of computer network security management and maintenance, regular anti-virus processing has important value. In particular, during a computer network attack, viruses are usually stored in a transmission medium. Once information is shared, it is easy to cause large-scale virus intrusion events, thus expanding the scope of virus intrusion, and even causing the possibility of computer network paralysis. However, the effectiveness of individual user killing or small-scale killing is not satisfactory. So in the actual management and maintenance process. Technicians will take the initiative to change the traditional concept of work, kill viruses regularly to eliminate the hidden dangers to the computer network security, especially the viruses in the front of the computer network, ensure that the computer network is in normal operation, and regularly update the virus database to try to prevent diversification.It is worth noting that computer network belongs to open system. Even if the virus on the computer in the network is removed, the possibility of secondary infection of the computer after connecting the computer to the network is much higher than that of other computers. Individual users and company users pay more attention to virus protection to achieve "three prohibitions", that is, no abnormal website, no pop-up window, no abnormal advertisement. Eliminate the risk of virus invasion from the root of the computer. Provide strong support for the normal operation of the network.The rapid development of the Internet era reflects the continuous development of modern technology. However, at the same time, the rapid development will also produce many problems waiting for people to solve. For network technology, security is the most important. This paper expounds the necessity of security maintenance from the basic concepts, main threats and maintenance measures. People believe that with the continuous development of the network, the continuous improvement of technology and people's security awareness and literacy, the security of the network system will be more and more guaranteed.