The expression of miR‐134‐5p has been previouslystudied in various diseases. For instance, miR‐134suppresses breast cancer progression by targetingKRAS.15,16 miR‐134 can inhibit gastric cancer cellproliferation via targeting GOLPH3.20 In addition,miR‐134 represses NSCLC migration and invasion bytargeting ITGB1. miR‐134canpromote atherosclero-sisdevelopment viaANGPTL4/LPL inApoEknockoutmice.22 However, to our knowledge, this is the firststudy of miR‐134 in neuropathic pain. Here, weobserved that miR‐134‐5p was decreased in CCI rat models. Overexpression of miR‐134‐5p strongly in-hibited neuropathic pain development.
The expression of miR‐134‐5p has been previously<br>studied in various diseases. For instance, miR‐134<br>suppresses breast cancer progression by targeting<br>KRAS.15,16 miR‐134 can inhibit gastric cancer cell<br>proliferation via targeting GOLPH3.20 In addition,<br>miR‐134 represses NSCLC migration and invasion by<br>targeting ITGB1. miR‐134canpromote atherosclero-<br>sisdevelopment viaANGPTL4/LPL inApoEknockout<br>mice.22 However, to our knowledge, this is the first<br>study of miR‐134 in neuropathic pain. Here, we<br>observed that miR‐134‐5p was decreased in CCI rat models. Overexpression of miR‐134‐5p strongly in-<br>hibited neuropathic pain development.
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