AbstractBackground Remote ischemic

AbstractBackground Remote ischemic perconditioning (RIPerC),remote ischemic postconditioning (RIPostC), and remoteischemic perconditioning ? postconditioning (RIPerC ? RIPostC) protect against renal ischemia reperfusioninjury (IRI). However, the most beneficial approach amongthese is not known.Aims To compare the protective effects and study themechanisms of three different remote ischemic conditioning in preventing IRI in the rat kidney.Methods Fifty healthy adult male Sprague–Dawley ratswere randomly assigned to five groups: sham, IRI, RIPerC,RIPostC, and RIPerC ? RIPostC. Right nephrectomy wasperformed initially in all rats. IRI was induced by occludingthe left renal artery for 60 min, followed by reperfusion for24 h. RIPerC, RIPostC, and RIPerC ? RIPostC wereinduced with 5-min ischemia/reperfusion (I/R) cycles usinga tourniquet on the right hind limb.Results The IRI group showed significant serologic evidence of renal injury compared to the sham group(P.05). The RIPerC, RIPostC, and RIperC ? RIpostC groups displayed significantly lower levels of renal dysfunction than the IRI group (P.05). Superoxidedismutase (SOD) levels were significantly lower in the IRIgroup than in the sham group (P = 0.003), but were significantly less depressed in the RIPerC, RIPostC, andRIperC ? RIpostC groups (P.05). The IRI group displayed more severe renal tubular injury than the RIPerC,RIPostC, and RIPerC ? RIPostC groups (P.05).Conclusion All three remote ischemic conditioningshowed similar therapeutic potential for preventing renalIRI. The RIPerC ? RIPostC protocol did not show anadditive effect from the combination of preconditioningand postconditioning. The protective mechanism may bedue to the stimulation of endogenous antioxidant activityby transient limb ischemia–reperfusion.

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摘要 背景远程缺血性预处理（RIPerC）， 远程缺血性后处理（RIPostC）和远程 缺血性预处理？后处理（RIP？erC？RIPostC）可防止肾脏缺血再灌注 损伤（IRI）。但是，其中最有益的方法 尚不清楚。 目的比较 三种不同的远程缺血性疾病预防大鼠肾脏IRI 的保护作用并研究其机制。 方法将50只健康的成年雄性Sprague–Dawley大鼠 随机分为5组：假手术，IRI，RIPERC， RIPostC和RIPerC？RIPostC。 最初在所有大鼠中进行右肾切除术。IRI是通过闭塞引起的 左肾动脉持续60分钟，然后再灌注 24小时。RIPerC，RIPostC和RIPerC？ 使用 右后肢的止血带以5分钟的缺血/再灌注（I / R）周期诱导RIPostC 。 结果与假手术组相比，IRI组显示出明显的肾脏损伤血清学证据 （P 0.05）。RIPerC，RIPostC和RIperC？RIpostC 组的肾功能不全水平明显低于IRI组（P 0.05）。 IRI 组的超氧化物歧化酶（SOD）水平显着低于假手术组（P = 0.003），但RIPerC，RIPostC和RIPerC显着降低 RIperC？RIpostC组（P 0.05）。IRI组比RIPerC， RIPostC和RIPerC 表现出更严重的肾小管损伤。RIPostC组（P 0.05）。 结论三种远端缺血性调理 在预防肾脏 IRI方面均具有相似的治疗潜力。RIPerC？RIPostC协议未显示 预处理 和后处理相结合的累加效果。保护机制可能是 由于 短暂的肢体缺血-再灌注刺激内源性抗氧化活性。

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结果 (简体中文) 2:[复制]

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Abstract Background Remote ischemic perconditioning (RIPerC), remote ischemic postconditioning (RIPostC), and remote ischemic perconditioning ? postconditioning (RIPerC ? RIPostC) protect against renal ischemia reperfusion injury (IRI). However, the most beneficial approach among these is not known. Aims To compare the protective effects and study the mechanisms of three different remote ischemic conditioning in preventing IRI in the rat kidney. Methods Fifty healthy adult male Sprague–Dawley rats were randomly assigned to five groups: sham, IRI, RIPerC, RIPostC, and RIPerC ? RIPostC. Right nephrectomy was performed initially in all rats. IRI was induced by occluding the left renal artery for 60 min, followed by reperfusion for 24 h. RIPerC, RIPostC, and RIPerC ? RIPostC were induced with 5-min ischemia/reperfusion (I/R) cycles using a tourniquet on the right hind limb. Results The IRI group showed significant serologic evidence of renal injury compared to the sham group (P0.05). The RIPerC, RIPostC, and RIperC ? RIpostC groups displayed significantly lower levels of renal dysfunction than the IRI group (P0.05). Superoxide dismutase (SOD) levels were significantly lower in the IRI group than in the sham group (P = 0.003), but were significantly less depressed in the RIPerC, RIPostC, and RIperC ? RIpostC groups (P0.05). The IRI group displayed more severe renal tubular injury than the RIPerC, RIPostC, and RIPerC ? RIPostC groups (P0.05). Conclusion All three remote ischemic conditioning showed similar therapeutic potential for preventing renal IRI. The RIPerC ? RIPostC protocol did not show an additive effect from the combination of preconditioning and postconditioning. The protective mechanism may be due to the stimulation of endogenous antioxidant activity by transient limb ischemia–reperfusion.

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结果 (简体中文) 3:[复制]

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摘要 背景远程缺血性渗出（RIPerC）， 远程缺血后处理（RIPostC）和远程 缺血性渗出？后处理（RIP erC？保护肾脏缺血再灌注 损伤（IRI）。然而，最有益的方法是 这些还不知道。 目的比较其保护效果，并对其进行研究 三种不同远端缺血状态对大鼠肾脏IRI的预防机制。 方法50只健康成年雄性Sprague-Dawley大鼠 随机分为5组：sham组、IRI组、riper组， RIPostC和RIPerC？里波斯克。右肾切除术 最初在所有大鼠中进行。闭塞诱导IRI 左肾动脉60min，再灌注 24小时。成熟，成熟，成熟？RIPostC是 用5分钟缺血/再灌注（I/R）周期诱导 右后肢上的止血带。 结果与假手术组相比，IRI组有明显的肾损伤血清学证据 （P.05）。成熟的，成熟的，成熟的？里波斯特 两组肾功能不全水平明显低于IRI组（P.05）。超氧化物 IRI组的SOD水平明显降低 与假手术组相比（P=0.003），但RIPerC、RIPostC和 成熟点？边缘组（P.05）。IRI组肾小管损伤较成熟组严重， RIPostC和RIPerC？边缘组（P.05）。 结论三者均为远程缺血预处理 在预防肾脏疾病方面显示出类似的治疗潜力 伊里。成熟的人？RIPostC协议没有显示 预处理组合的加性效应 以及后处理。保护机制可能是 由于内源性抗氧化活性的刺激 通过短暂的肢体缺血再灌注。

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