The basic requirement of power grid operation is safety and stability. The core problem of power grid security and stability is to establish a reasonable power grid structure suitable for power supply network. The status and function of 110kV power grid and substation in the system have changed greatly. The 110kV power grid has been simplified into a distribution network, and most of the 110kV substations have also been simplified into load-type terminal substations. With the increase of distribution voltage, the safety of power system must be paid attention to all the time. In the construction of the substation, it is necessary to ensure the economy and flexibility of the substation, as well as the safety of the substation. With the continuous efforts of the electrician, the design of the substation will be improved.