Recommendation 3.4. A combined regi

Recommendation 3.4. A combined regimen of pharmacologic and mechanical prophylaxis may improve ef- ficacy, especially in the highest-risk patients (Type: evidence based; Evidence quality: intermediate; Strength of recommendation: moderate).Recommendation 3.5. Pharmacologic thromboprophylaxis for patients undergoing major surgery for cancer should be continued for at least 7 to 10 days. Extended prophylaxis with LMWH for up to 4 weeks post- operatively is recommended for patients undergoing major open or laparoscopic abdominal or pelvic surgery for cancer who have high-risk features, such as restricted mobility, obesity, history of VTE, or with additional risk factors. In lower-risk surgical settings, the decision on appropriate duration of thromboprophylaxis should be made on a case-by-case basis (Type: evidence based; Evidence quality: high; Strength of recommen- dation: moderate to strong