Objectives: To study if four cycles

Objectives: To study if four cycles of remote ischaemic preconditioning could offer protection againstcontrast induced nephropathy (CIN) and post procedural renal dysfunction in high risk patientsundergoing percutaneous coronary intervention (PCI).Methods: This was a prospective single blind randomised sham controlled trial where patientsundergoing coronary angioplasty with stage III chronic kidney disease were randomised into shampreconditioning and remote ischaemic preconditioning. The primary outcome was the reduction in theincidence of CIN. The secondary outcomes were the maximum improvement in eGFR, maximumreduction in serum creatinine and composite of requirement of haemodialysis, death andrehospitalisation for heart failure up to 6 weeks after PCI.Results: Eleven out of fifty patients in the study group developed CIN (22%) compared to eighteen out ofthe fifty control patients (36%) {p = 0.123}. There was a statistically significant improvement in the postprocedure creatinine values at 24 h {p = 0.013}, 48 h {p = 0.015}, 2 weeks {p = 0.003}, 6 weeks {p = 0.003}and post procedure glomerular filtration rate (eGFR) values at 24 h {p = 0.026}, 48 h {p = 0.044}, 2 weeks{p = 0.015} and 6 weeks {p = 0.011} in study group compared to control group. The secondary outcomecomposite of requirement of haemodialysis, death and rehospitalisation for heart failure was notstatistically significant {p: 0.646}.Conclusion: RIPC does not result in significant reduction of CIN. However RIPC helps in the prevention ofpost procedural worsening in eGFR and serum creatinine even up to 6 weeks.

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结果 (简体中文) 1: [复制]

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目的：研究 在 接受经皮冠状动脉介入治疗（PCI）的高危患者中，四个周期的远程缺血预处理能否提供针对造影剂肾病（CIN）和术后肾功能不全的保护。 方法：这是一项前瞻性单盲随机假手术对照试验，其中将患有 III期慢性肾脏疾病的冠状动脉血管成形术患者随机分为假手术 预处理和远程缺血预处理。主要结果是降低 了CIN 的发生率。次要结果是eGFR的最大改善， 血清肌酐的最大减少以及血液透析，死亡和死亡的综合需求 PCI后长达6周的心力衰竭再次住院治疗。 结果：研究组的五十名患者中有十一名发生了CIN（22％）， 而五十名对照组患者中有十八名（36％）出现了CIN {p = 0.123}。术后 24小时{p = 0.013}，48 h {p = 0.015}，2周{p = 0.003}，6周{p = 0.003} 和术后肾小球滤过率的肌酐值有统计学上的显着改善 与对照组相比，研究组在24 h {p = 0.026}，48 h {p = 0.044}，2周{p = 0.015}和6周{p = 0.011}时的（eGFR）值。 因心力衰竭需要进行血液透析，死亡和再次住院的次要结局指标在 统计学上不显着{p：0.646}。 结论：RIPC不会导致CIN显着降低。然而，RIPC有助于预防 eGFR和血清肌酐的治疗后恶化，甚至长达6周。

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结果 (简体中文) 2:[复制]

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Objectives: To study if four cycles of remote ischaemic preconditioning could offer protection against contrast induced nephropathy (CIN) and post procedural renal dysfunction in high risk patients undergoing percutaneous coronary intervention (PCI). Methods: This was a prospective single blind randomised sham controlled trial where patients undergoing coronary angioplasty with stage III chronic kidney disease were randomised into sham preconditioning and remote ischaemic preconditioning. The primary outcome was the reduction in the incidence of CIN. The secondary outcomes were the maximum improvement in eGFR, maximum reduction in serum creatinine and composite of requirement of haemodialysis, death and rehospitalisation for heart failure up to 6 weeks after PCI. Results: Eleven out of fifty patients in the study group developed CIN (22%) compared to eighteen out of the fifty control patients (36%) {p = 0.123}. There was a statistically significant improvement in the post procedure creatinine values at 24 h {p = 0.013}, 48 h {p = 0.015}, 2 weeks {p = 0.003}, 6 weeks {p = 0.003} and post procedure glomerular filtration rate (eGFR) values at 24 h {p = 0.026}, 48 h {p = 0.044}, 2 weeks {p = 0.015} and 6 weeks {p = 0.011} in study group compared to control group. The secondary outcome composite of requirement of haemodialysis, death and rehospitalisation for heart failure was not statistically significant {p: 0.646}. Conclusion: RIPC does not result in significant reduction of CIN. However RIPC helps in the prevention of post procedural worsening in eGFR and serum creatinine even up to 6 weeks.

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结果 (简体中文) 3:[复制]

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目的：研究四个周期的远程缺血预处理是否能保护机体免受缺血预处理的影响 造影剂诱导肾病（CIN）与高危患者术后肾功能不全 接受经皮冠状动脉介入治疗。 方法：这是一个前瞻性单盲随机假对照试验 接受冠状动脉成形术的III期慢性肾脏病患者被随机分为假手术组 预处理和远程缺血预处理。主要结果是 CIN的发病率。次要结果是eGFR的改善最大，最大 血清肌酐降低和血液透析、死亡和 PCI术后6周内心力衰竭的再住院治疗。 结果：研究组50例患者中有11例（22%）出现CIN，相比之下，18例出现CIN 对照组50例（36%）{p=0.123}。这一职位在统计上有显著改善 24小时{p=0.013}，48小时{p=0.015}，2周{p=0.003}，6周{p=0.003}时的肌酐值 术后24h肾小球滤过率（eGFR）值，48h{p=0.044}，2周 研究组与对照组比较{p=0.015}和6周{p=0.011}。次要结果 对血液透析、死亡和心力衰竭再住院的要求的复合物没有 统计显著{p:0.646}。 结论：RIPC对CIN无明显降低作用。然而，RIPC有助于预防 术后eGFR和血清肌酐恶化，甚至长达6周。

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