Researchers have long been studying the connection between health and the five major personality traits: agreeableness, extraversion, neuroticism, openness and conscientiousness. A large body of research _1_ neuroticism with poorer health and conscientiousness with superior health. Now openness, which measures cognitive flexibility and the willingness to _2_ novel ideas, has _3_ as a lifelong protective factor. The _4_ seems to be the creativity _5_ the personality trait-creative thinking reduces stress and keeps the brain healthy.