Background Acute kidney injury (AKI

Background Acute kidney injury (AKI) is one of the most common emergencies and severe diseases in the clinic. We sought toverify whether remote ischemic preconditioning (RIPC) has a protective effect on the kidney of child with congenital heartdisease undergoing cardiopulmonary bypass (CPB) surgery. We hypothesized it may be related to the up-regulation ofmicroRNA-21 (miR-21).Methods We performed a prospective randomized clinical study among children with congenital heart disease undergoing CPBsurgery between January and December 2016. Children were randomized to an RIPC or control group. Patients in each groupwere divided into an AKI and a non-AKI group according to the occurrence of AKI at 48 h after surgery. Remote ischemicpreconditioning (RIPC) conducted by blood-pressure cuff was performed 12 h before surgery. Serum creatinine (SCr), tumornecrosis factor-α (TNF-α), and miR-21 expression in blood and urine were measured at different time points.Results A total of 449 cases (200 RIPC; 249 controls) were enrolled. The male/female ratio was 1.18, with a mean age of 37.50 ±25.31 months. The incidence of AKI in the RIPC group was significantly lower than that in the control group (19.0% vs. 46.2%,P

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结果 (简体中文) 1: [复制]

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背景技术急性肾损伤（AKI）是临床上最常见的紧急情况和严重疾病之一。我们试图 验证远程缺血预处理（RIPC）对 接受心肺转流（CPB）手术的先天性心脏病患儿的肾脏是否具有保护作用。我们假设这可能与 microRNA-21（miR-21）的上调有关。 方法我们对 2016年1月至2016年12月接受CPB 手术的先天性心脏病患儿进行了一项前瞻性随机临床研究。将这些患儿随机分为RIPC组或对照组。 根据术后48 h AKI的发生情况，将各组患者分为AKI组和非AKI组。远端缺血 在手术前12小时通过血压袖带进行预处理（RIPC）。 在不同的时间点测量血肌酐（SCr），肿瘤坏死因子-α（TNF-α）和miR-21在血液和尿液中的表达。 结果共纳入449例（200例RIPC； 249例对照）。男女比例为1.18，平均年龄为37.50± 25.31个月。RIPC组的AKI发生率显着低于对照组（19.0％对46.2％， P

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结果 (简体中文) 2:[复制]

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Background Acute kidney injury (AKI) is one of the most common emergencies and severe diseases in the clinic. We sought to verify whether remote ischemic preconditioning (RIPC) has a protective effect on the kidney of child with congenital heart disease undergoing cardiopulmonary bypass (CPB) surgery. We hypothesized it may be related to the up-regulation of microRNA-21 (miR-21). Methods We performed a prospective randomized clinical study among children with congenital heart disease undergoing CPB surgery between January and December 2016. Children were randomized to an RIPC or control group. Patients in each group were divided into an AKI and a non-AKI group according to the occurrence of AKI at 48 h after surgery. Remote ischemic preconditioning (RIPC) conducted by blood-pressure cuff was performed 12 h before surgery. Serum creatinine (SCr), tumor necrosis factor-α (TNF-α), and miR-21 expression in blood and urine were measured at different time points. Results A total of 449 cases (200 RIPC; 249 controls) were enrolled. The male/female ratio was 1.18, with a mean age of 37.50 ± 25.31 months. The incidence of AKI in the RIPC group was significantly lower than that in the control group (19.0% vs. 46.2%, P

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结果 (简体中文) 3:[复制]

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背景急性肾损伤（AKI）是临床上最常见的急症和严重疾病之一。我们试图 验证远程缺血预处理（RIPC）对先天性心脏病患儿肾脏的保护作用 正在进行体外循环（CPB）手术的疾病。我们推测这可能与 microRNA-21（miR-21）。 方法对先天性心脏病行体外循环的患儿进行前瞻性随机临床研究 2016年1月至12月的手术。儿童被随机分为RIPC组或对照组。每组患者 根据术后48h AKI的发生情况分为AKI组和非AKI组。远端缺血 术前12h用血压袖带进行预处理。血清肌酐（SCr），肿瘤 检测不同时间点血和尿中坏死因子-α（TNF-α）和miR-21的表达。 结果共纳入449例（200例RIPC，249例对照）。男女之比为1.18，平均年龄为37.50± 25.31个月。RIPC组的AKI发生率明显低于对照组（19.0%对46.2%， P

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