Measurements and Main Results: The

Measurements and Main Results: The primary endpoint of the interventional part was change in urinary [tissue inhibitor of metalloproteinases-2]*[insulin-like growth factor–binding protein 7] between pre- and postintervention. To examine secondary objectives including acute kidney injury incidence, we included an observational cohort. A total of 180 patients were included in the trial (n = 80 observational and n = 100 randomized controlled part [20 patients/group]). The mean age was 69.3 years (10.5 yr), 119 were men (66.1%). Absolute changes in [tissue inhibitor of metalloproteinases-2]*[insulin-like growth factor–binding protein 7] were significantly higher in all remote ischemic preconditioning groups when compared with controls (p < 0.01). Although we did not observe a dose-response relationship on absolute changes in [tissue inhibitor of metalloproteinases-2]*[insulin-like growth factor–binding protein 7] across the four different remote ischemic preconditioning groups, in the 15 patients failing to respond to the lowest dose, nine (60%) responded to a subsequent treatment at a higher intensity. Compared with controls, fewer patients receiving remote ischemic preconditioning developed acute kidney injury within 72 hours after surgery as defined by both Kidney Disease: Improving Global Outcomes criteria (30/80 [37.5%] vs 61/100 [61.0%]; p = 0.003).

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结果 (简体中文) 1: [复制]

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测量和主要结果： 干预部分的主要终点是干预 前和干预后尿液[ 金属蛋白酶组织抑制剂-2] * [胰岛素样生长因子结合蛋白7]的变化。为了检查包括急性肾损伤发生率在内的辅助目标，我们 纳入了一个观察性队列。 试验共纳入180名患者（n = 80观察者和n = 100随机对照部分[20患者/组]）。平均年龄为 69.3岁（10.5岁），其中119人为男性（66.1％）。在所有偏远地区 ，[金属蛋白酶-2抑制剂] * [胰岛素样生长 因子结合蛋白7]的绝对变化均显着较高。 与对照组相比，缺血预处理组 （p <0.01）。尽管我们 在四个不同的远程缺血预处理组中未观察到[金属蛋白酶2的组织抑制剂] * [胰岛素样生长因子结合蛋白7]的绝对变化的剂量反应关系，但在 15个对最低剂量无效的患者中，有九名（60％） 对更高剂量的后续治疗有反应。与对照组相比，较少的接受远程缺血 预处理的患者在 两种肾脏疾病定义的手术后72小时内出现急性肾损伤：改善 总体结果标准（30/80 [37.5％] vs 61/100 [61.0％]； p = 0.003）。

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结果 (简体中文) 2:[复制]

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Measurements and Main Results: The primary endpoint of the interventional part was change in urinary [tissue inhibitor of metalloproteinases-2]*[insulin-like growth factor–binding protein 7] between pre- and postintervention. To examine secondary objectives including acute kidney injury incidence, we included an observational cohort. A total of 180 patients were included in the trial (n = 80 observational and n = 100 randomized controlled part [20 patients/group]). The mean age was 69.3 years (10.5 yr), 119 were men (66.1%). Absolute changes in [tissue inhibitor of metalloproteinases-2]*[insulin-like growth factor–binding protein 7] were significantly higher in all remote ischemic preconditioning groups when compared with controls (p < 0.01). Although we did not observe a dose-response relationship on absolute changes in [tissue inhibitor of metalloproteinases-2]*[insulin-like growth factor–binding protein 7] across the four different remote ischemic preconditioning groups, in the 15 patients failing to respond to the lowest dose, nine (60%) responded to a subsequent treatment at a higher intensity. Compared with controls, fewer patients receiving remote ischemic preconditioning developed acute kidney injury within 72 hours after surgery as defined by both Kidney Disease: Improving Global Outcomes criteria (30/80 [37.5%] vs 61/100 [61.0%]; p = 0.003).

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结果 (简体中文) 3:[复制]

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主要测量结果和终点 介入部分为尿[组织抑制物]改变 干预前后金属蛋白酶-2]*[胰岛素样生长因子结合因子7]。为了检查次要目标，包括急性肾损伤的发生率，我们 包括一个观察队列。共有180名患者 纳入试验（n=80个观察组，n=100个随机对照组[20名患者/组]）。平均年龄是 69.3岁（10.5岁），男性119例（66.1%）。绝对变化 [金属蛋白酶组织抑制剂-2]*[胰岛素样生长 因子结合蛋白7]在所有远端组织中显著升高 缺血预处理组与对照组比较 （p<0.01）。尽管我们没有观察到金属蛋白酶组织抑制剂-2]*[胰岛素样生长因子-结合蛋白7]的绝对变化的剂量-反应关系 四个不同的远程缺血预处理组 15名患者对最低剂量无效，9名（60%） 对随后的高强度治疗有反应。与对照组相比，接受远端缺血的患者更少 预处理在72小时内发生急性肾损伤 术后两种肾脏疾病的定义：改善 全球结果标准（30/80[37.5%]vs 61/100[61.0%]； p=0.003）。

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