In this regard, it is well documented that retinol treatment(human clinical)reduces matrix metalloprotease expression and stimulates collagen synthesis in naturally aged, sun-protected skin and, perhaps more importantly, in photodamaged skin.51 Given the many similar targets of retinol and bakuchiol, Chaudhuri compared the performance of bakuchiol and retinol on two key matrix metalloproteases, MMP-1 and MMP-12.